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KMID : 0363120120250010025
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Korean Journal of Pain
2012 Volume.25 No. 1 p.25 ~ p.32
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Efficacy of Glycopyrrolate in Primary Hyperhidrosis Patients
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Lee Hyun-Ho
Kim Do-Won
Kim Do-Wan
Kim Chan
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Abstract
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Background: Primary hyperhidrosis is a disorder of excessive sweating, which shares several features with anxiety disorders and has a negative impact on a patient’s quality of life. Oral glycopyrrolate is one of the treatments available. There are a few published studies on the use of glycopyrrolate given orally in the treatment of hyperhidrosis.
Methods: Thies is study was a review of case notes in a series of 36 patients with primary hyperhidrosis. We made a comparison between the Keller’s scale score of a pre-glycopyrrolate medication group and the Keller’s scale score f a post-glycopyrrolate medication group. The Milanez de Campos score, Short Form_36 (SF-36) score, Beck Depression Inventory (BDI) score, Beck Anxiety Inventory (BAI) score, and autonomic nervous system (ANS) scale score were also compared between the two groups.
Results: In the post-glycopyrrolate medication group, there were declines in Keller’s scale, and Milanez de Campos scale score and BAI score (P ＜ 0.001). In addition, there were increases in SF_36 score in the post-glycopyrrolate medication group (P = 0.03) However, no changes were seen in, BDI score and ANS score in the post-glycopyrrolate medication group (P ＜ 0.001).
Conclusions: Glycopyrrolate is an effective initial method of treating primary hyperhidrosis that, reduces anxiety and improve patients’ quality of life.
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KEYWORD
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anticholinergic agents, glycopyrrolate, primary hyperhidrosis
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